Abstract
The oncologic outcome of laparoscopic radical gastrectomy (LG) with open radical gastrectomy (OG) for gastric cancer with preoperative enlarged lymph nodes (LNs) remains ambiguous. The long-term outcomes of LG (n=855) versus OG (n=154) in gastric adenocarcinoma patients were analyzed retrospectively. Patients were stratified according to enlarged (>10mm) and small (≤10mm) LNs (ELN and SLN) based on the long-axis diameter of the LNs. The violin plot indicates that the distribution of ELN size was similar between two groups. Survival curves demonstrated that the overall survival (OS) in LG is enhanced compared with OG (p=0.034). A stratified analysis revealed that the OS was better in the LG group compared with the OG group for patients with ELNs (p=0.038). In a forest map analysis, the actual 3-year OS rate for LG was significantly increased compared with OG in enlarged suprapancreatic LN (ESLNs) patients. Stratified analysis based on different diameters of ESLNsrevealed that the actual 3-year OS and cancer-specific survival (CSS)rate for LG was significant increased compared to OG with a diameter from 1.0 to 1.9cm for pII or pIII stage patients. However, the actual 3-year OS and CSS rate for LG was significantly reduced compared with OG when the size exceeded 2.5cm. For advanced gastric cancer with an ESLN diameter from 1.0 to 1.9cm, LG couldbe chosen preferentially; nevertheless, LG is not safe if ESLN are>2.5 cm.
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