Abstract
Problem statement: Global warming is one of most significant factors affecting the biological evolution and the influenza is the disease that threatens humans with possible epidemics or pandemics. It would be important to understand if the global warming would have potential impact on the evolution of influenza virus. For this aim, the first would be to study the trend of evolution of proteins from influenza A virus and compare it with the trend in global warming. Approach: The evolution of polymerase acidic proteins of influenza A virus from 1918-2008 was defined using the unpredictable portion of amino-acid pair predictability. Then the trend in this evolution was compared with the trend in the global temperature, the temperature in north and south hemispheres and the temperature in influenza A virus sampling site and species carrying influenza A virus. Results: The similar trend was found between global warming and evolution of polymerase acidic proteins although we could not correlate them at this stage of study. Conclusion: The study suggested the potential impact of global warming on the evolution of proteins from influenza A virus.
Highlights
It is said that the climate change has an extinction risk for many species[1]
The protein evolution is a process of mutations within protein family, but definitely we cannot identify all the mutation causes one by one because some cause that led to mutations in the past might not leave any trace due to the environment changes
There are many other ways to change a protein into a datum, for example, we can use the physicochemical property of amino acid to change a protein into a numeral sequence[7], the physicochemical property is not subject to mutations, which engineer the evolution, so we cannot use this approach to plot the evolution of a protein family over time
Summary
It is said that the climate change has an extinction risk for many species[1]. If so, we would expect to see that the protein evolution would be affected to some degree some proteins could be hidden deeply inside cells. It is certain that all the mutation causes leave their traces in protein, whose amino acids differ over evolutionary process. We need to change a 20-letter symbolized protein into a number, more accurate, a scalar datum, because the scalar data are far easy to present in coordinates along the time course as an evolutionary process. There are many other ways to change a protein into a datum, for example, we can use the physicochemical property of amino acid to change a protein into a numeral sequence[7], the physicochemical property is not subject to mutations, which engineer the evolution, so we cannot use this approach to plot the evolution of a protein family over time. We have tested many proteins to verify this request and got the positive answer[2,3,4,5]
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