Abstract
BackgroundInsufficient data describe the relationship of hemodynamic parameters to left ventricular (LV) diastolic flow propagation velocity (Vp) measured using color M-mode Doppler echocardiography.MethodsAn in vitro LV model used to simulate LV diastolic inflow with Vp measured under conditions of varying: 1) Stroke volume, 2) heart rate (HR), 3) LV volume, 4) LV compliance, and 5) transmitral flow (TMF) waveforms (Type 1: constant low diastasis flow and Type 2: no diastasis flow).ResultsUnivariate analysis revealed excellent correlations of Vp with stroke volume (r = 0.98), LV compliance (r = 0.94), and HR with Type 1 TMF (r = 0.97). However, with Type 2 TMF, HR was not associated with Vp. LV volume was not related to Vp under low compliance, but inversely related to Vp under high compliance conditions (r = -0.56).ConclusionThese in vitro findings may help elucidate the relationship of hemodynamic parameters to early diastolic LV filling.
Highlights
Insufficient data describe the relationship of hemodynamic parameters to left ventricular (LV) diastolic flow propagation velocity (Vp) measured using color M-mode Doppler echocardiography
Rt0Fr.ei1agln5aus,trmipoein=t5srhaNlipSfl)obwetwpaetetnerhne: aHrtRrwataes(nHoRt)asasnodcViaptewdiwthitah TVypp(er2= Relationship between heart rate (HR) and Vp with a Type 2 transmitral flow pattern: HR was not associated with Vp (r = 0.15, p = NS)
The LV volume was not associated with Vp at stroke volume (SV) 50 ml (r = -0.08, p = NS) and SV 70 ml (r = 0.04, p = NS) under low compliance conditions
Summary
Insufficient data describe the relationship of hemodynamic parameters to left ventricular (LV) diastolic flow propagation velocity (Vp) measured using color M-mode Doppler echocardiography. The flow Vp of early diastolic LV inflow measured using color M-mode Doppler echocardiography (CMD) has been recognized as a useful measure of LV relaxation. [1,3,4] there are few published data describing the relationship of hemodynamic parameters to Vp. In the clinical and in vivo experimental situations, it is difficult to evaluate the influence of any single hemodynamic variable on Vp because changing one variable often is associated with changes in other variables, such as LV contraction and heart rate. Performed in vitro CMD studies using a mechanical LV model which allowed us to produce isolated changes in the hemodynamic parameters
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