Abstract
ABSTRACTIschemia-reperfusion injury is a pathophysiological event occuring after abdominal organ transplantation, and has a significant influence on prognosis and survival of the graft. It is involved in delaying the primary function or non-functioning of the graft. The objective of this study was to provide information on heat shock protein mechanisms in ischemia-reperfusion injuries in abdominal organ transplantations, and to indicate the possible factors involved that may influence the graft outcome. Several classes of heat shock proteins are part of the ischemia and reperfusion process, both as inflammatory agonists and in protecting the process. Studies involving heat shock proteins enhance knowledge on ischemia-reperfusion injury mitigation processes and the mechanisms involved in the survival of abdominal grafts, and open space to support therapeutic future clinical studies, minimizing ischemia and reperfusion injuries in abdominal organ transplantations. Expression of heat shock proteins is associated with inflammatory manifestations and ischemia-reperfusion injuries in abdominal organ transplantations and may influence graft outcomes.
Highlights
INTRODUCTION Heat shock proteinsHeat shock proteins (HSP) are part of a large family of proteins and are found in virtually all organs and tissues.[1]
Studies involving heat shock proteins enhance knowledge on ischemia-reperfusion injury mitigation processes and the mechanisms involved in the survival of abdominal grafts, and open space to support therapeutic future clinical studies, minimizing ischemia and reperfusion injuries in abdominal organ transplantations
❚❚INTRODUCTION Heat shock proteins Heat shock proteins (HSP) are part of a large family of proteins and are found in virtually all organs and tissues.[1]. Heat shock proteins are essential in a wide variety of intracellular processes, such as protein folding, assembly, disassembly and intracellular localization; and secretion, regulation and degradation of other proteins.[2,3] They have an important protective role, both under stress-free conditions,(4) and during ischemic or oxidative stress, inflammatory processes, intracellular energy depletion, hormonal processes, apoptosis, among others.[2,5] These stress factors occur in patients undergoing abdominal organ transplantation, and the ability to withstand such stressors is closely linked to the success of the procedure
Summary
Igor Lepski Calil, Francisco Tustumi, Jorge Henrique Bento de Sousa, Bruno Martins Tomazini, Ruy Jorge Cruz Jr4, Gustavo Niankowski Saliba, Rafael Antonio Arruda Pécora, Luiz Augusto Carneiro D’Albuquerque. Ischemia-reperfusion injury is a pathophysiological event occuring after abdominal organ transplantation, and has a significant influence on prognosis and survival of the graft. It is involved in delaying the primary function or non-functioning of the graft. The objective of this study was to provide information on heat shock protein mechanisms in ischemia-reperfusion injuries in abdominal organ transplantations, and to indicate the possible factors involved that may influence the graft outcome. Studies involving HSPs allow for greater knowledge on the processes controlling attenuation of I/R injuries and the mechanisms involved in the survival of abdominal grafts, and open space to support future clinical therapeutic studies, minimizing I/R injuries in abdominal organ transplantations.
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