Abstract
Evidence-Based Answer For patients with CMC, 6-month therapy with a systemic azole may be effective (SOR: B, single RCT). Daily oral fluconazole has been recommended as first-line treatment (SOR: C, expert opinion). Should resistance develop, treatment should be individualized based on Candida albicans culture susceptibility and clinical response; options include posaconazole, echinocandins, and amphotericin B, with the need for maintenance antifungal therapy likely (SOR: C, case reports and expert opinion).
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