Abstract
Working memory has never been so well established as a construct for understanding psychopathology. In fact, it is one of a select few constructs around which new thinking about pathophysiology in mental illness is being organized. As the construct gains in prominence, so does interest in finding out what precisely about working memory goes wrong, leading to psychiatric symptoms. In refining our ideas about what goes wrong in working memory, we may overturn the whole apple cart of current thinking. Failure of Schizophrenia Patients to Overcome Salient Distractors During Working Memory EncodingBiological PsychiatryVol. 68Issue 7PreviewPrior demonstrations of impaired attentional control in schizophrenia focused on conditions in which top-down control is needed to overcome prepotent response tendencies. Attentional control over stimulus processing has received little investigation. Here, we test whether attentional control is impaired during working memory encoding when salient distractors compete with less salient task-relevant stimuli. Full-Text PDF Alpha Phase Locking Predicts Residual Working Memory Performance in SchizophreniaBiological PsychiatryVol. 68Issue 7PreviewWorking memory (WM) deficits are a core feature of schizophrenia. Recent electrophysiological evidence indicates that the brain systems for visual encoding are especially impaired. However, patients still achieve performance levels clearly above chance, which indicates the existence of residual mechanisms supporting WM encoding. The present study presents evidence that alpha phase locking of the electroencephalogram is a marker for such residual cognitive mechanisms. Full-Text PDF
Published Version
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