Abstract
What is a Seizure? Insights from Human Single-Neuron Recordings
Highlights
The array was placed in an area that was likely to be resected in epilepsy surgery
They investigated single-neuron firing during eight seizures by routine intracranial EEG prior to epilepsy surgery. They distinguished between the interictal, preictal, ictal, and postictal periods. They found that neuronal firing rate increased in 45.5% of all recorded neurons and decreased in 9.9%
Heterogeneity of firing patterns increased at seizure onset, as reflected by a measure of variance, the Fano Factor (Figure 1)
Summary
They investigated single-neuron firing during eight seizures by routine intracranial EEG prior to epilepsy surgery. They found that neuronal firing rate increased in 45.5% of all recorded neurons and decreased in 9.9%. At the onset of the seizure, neuronal firing did not uniformly increase as expected in a purely excitatory event.
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