Abstract
Abstract This chapter reviews the history, technology, and scientific contributions of single-neuron recordings in humans, which have largely been conducted in epilepsy patients undergoing surgical procedures for clinical treatment purposes. Single-neuron recordings have been used by epileptologists to study interictal discharges and the onset, propagation, and termination of human focal seizures, and by neuroscientists and biomedical engineers to study normal cognition in areas such as visual and spatial memory and decision-making. While there are many practical and ethical limitations, this work has proven invaluable for both exploratory studies and for validating research from animal or computational models. Ongoing technological innovation is likely to expand the use and applicability of human single-neuron studies in the foreseeable future.
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