WELL DIFFERENTIATED SQUAMOUS CELL CARCINOMA OF THE MOUTH´S FLOOR: REPORT OF A HIGHLY AGGRESSIVE CASE

Abstract

A 67-year-old male patient, smoker and alcoholic, presented lesions in the anterior region of the mouth's floor, with painful symptoms and limited mouth opening, reporting six months of evolution. Upon clinical examination, an exophytic and ulcerated lesion measuring approximately 3 cm was observed, which prevented lingual mobility. An incisional biopsy was performed, followed by a histopathological examination that revealed an epithelial malignant neoplasm characterized by the cell proliferation arranged in nests, islands, and cords, in addition to the presence of numerous keratin pearls. Cell and nuclear pleomorphisms were also observed, with large cells showing a loss of the nucleus/cytoplasm ratio, hyperchromatic atypical nucleus or with evident nucleolus, and the presence of atypical mitoses, leading to the diagnosis of well-differentiated squamous cell carcinoma. The patient was referred to the oncology center and died 1 month after starting radiotherapy. A 67-year-old male patient, smoker and alcoholic, presented lesions in the anterior region of the mouth's floor, with painful symptoms and limited mouth opening, reporting six months of evolution. Upon clinical examination, an exophytic and ulcerated lesion measuring approximately 3 cm was observed, which prevented lingual mobility. An incisional biopsy was performed, followed by a histopathological examination that revealed an epithelial malignant neoplasm characterized by the cell proliferation arranged in nests, islands, and cords, in addition to the presence of numerous keratin pearls. Cell and nuclear pleomorphisms were also observed, with large cells showing a loss of the nucleus/cytoplasm ratio, hyperchromatic atypical nucleus or with evident nucleolus, and the presence of atypical mitoses, leading to the diagnosis of well-differentiated squamous cell carcinoma. The patient was referred to the oncology center and died 1 month after starting radiotherapy.