Abstract
BackgroundSeveral studies have been performed to investigate the associations between interleukin (IL)-8 rs4073 polymorphism and acute pancreatitis (AP), but the results are inconclusive. We conducted this cumulative meta-analysis for a precise estimate of the relationship between IL-8 rs4073 polymorphism and acute pancreatitis.MethodsWe searched the electronic databases for relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations. For a better presentation of how the pooled ORs changed as updated evidence accumulated, we used forest plots from a cumulative meta-analysis method.ResultsTen studies involving 1646 AP patients and 1816 controls were finally included in this meta-analysis. Cumulative meta-analyses indicated there is a consistent trend toward association after the initial discovery. Under the allelic, dominant, recessive and homozygous models, the pooled ORs were 1.265 (1.147–1.395, p < 0.001), 1.304 (1.127–1.508, p < 0.001), 1.431 (1.203–1.702, p < 0.001), and 1.634 (1.334–2.001, p < 0.001), respectively.ConclusionsThis meta-analysis demonstrated a suggestive result that people who carried the risk A allele of the IL-8 rs4073 polymorphism may be more sensitive to acute pancreatitis.
Highlights
Several studies have been performed to investigate the associations between interleukin (IL)-8 rs4073 polymorphism and acute pancreatitis (AP), but the results are inconclusive
Interleukin (IL)-8 stands out in the AP pathophysiology as it has been demonstrated to be significantly elevated during the pathological course of AP, and the level was reported to be associated with the severity of AP [4,5,6]
Inclusion and exclusion criteria Qualified studies have to meet the following criteria: (1) predefined diagnosis criteria for AP; (2) case-control studies evaluated the association between the IL-8 rs4073 polymorphism and AP risk; (3) provided detailed genotype frequencies; (4) if multiple reports based on the same study population were available, the most recent or largest study was selected
Summary
Several studies have been performed to investigate the associations between interleukin (IL)-8 rs4073 polymorphism and acute pancreatitis (AP), but the results are inconclusive. We conducted this cumulative metaanalysis for a precise estimate of the relationship between IL-8 rs4073 polymorphism and acute pancreatitis. The pathophysiological progress involves a local and systematic inflammatory response to the autodigestion of the pancreatic tissue, and inflammation plays an integral role [3]. Due to the contradictory and inconclusive results, we performed this meta-analysis to clarify the correlation between IL-8 rs4073 polymorphism and AP risk
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