Abstract
Background:Primary studies have shown that the IL-12B rs3212227 and IL-6 rs1800795 polymorphisms are associated with an increased risk of cervical cancer. However, conflicting results warrant a meta-analysis to obtain more precise estimates. Methods:A comprehensive literate search on PubMed, Web of Science, Scopus, CNKI, and SciELO was performed to collect all eligible studies up to November 10, 2019. The pooled odds ratios (OR) and 95% confidence intervals (CI) were used to calculate the risk. This meta-analysis was carried out by utilizing CMA software. Results:A total of eleven case-control studies including four studies on IL-12B rs3212227 and seven studies on IL-6 rs1800795 were selected. Pooled ORs revealed that the IL-6 rs1800795 polymorphism was significantly associated with an increased risk of cervical cancer (C vs. G: OR = 1.294, 95% CI 1.071-1.564, p= 0.007; CC vs. GG: OR = 1.633, 95% CI 1.059-2.520, p= 0.027; CC+CG vs. GG: OR = 1.312, 95% CI 1.048-1.643, p= 0.018; and CC vs. CG+GG: OR = 1.592, 95% CI 1.268-1.999, p≤0.001), but not IL-12B rs3212227 polymorphism. Stratified analysis by ethnicity revealed that both IL-12B rs3212227 and IL-6 rs1800795 polymorphisms were associated with risk of cervical cancer in Asian women. Conclusions:Our pooled data revealed that the IL-12B rs3212227 and IL-6 rs1800795 polymorphisms may be used to identify individuals at high risk of cervical cancer in Asian women.
Highlights
Cervical cancer is the second most commonly diagnosed malignancy and third leading cause of cancer-related mortality among women in less developed countries (Karimi Zarchi et al, 2010; Mousavi et al, 2008)
Including and Excluding Criteria We set these inclusive criteria for recruited publications: a) studies with case-control or cohort design; 2) published studies in English, Chinese and Farsi; 3) studies evaluated the association of IL-12B rs3212227 and IL-6 rs1800795 polymorphisms with risk of cervical cancer; and 4) enough and available data to figure out odds ratios (ORs) and 95% confidence intervals (CIs)
Characteristics of Included Studies By electronic and manual searches concerning the association of IL-12B rs3212227 and IL-6 rs1800795 polymorphisms and cervical cancer risk, 297 relevant studies up to November 05, 2019 were identified
Summary
Cervical cancer is the second most commonly diagnosed malignancy and third leading cause of cancer-related mortality among women in less developed countries (Karimi Zarchi et al, 2010; Mousavi et al, 2008). According to GLOBOCAN, cervical cancer accounts for 528,000 new cases and 266,000 deaths worldwide in 2012 (Parkin et al, 2005). Primary studies have shown that the IL-12B rs3212227 and IL-6 rs1800795 polymorphisms are associated with an increased risk of cervical cancer. The pooled odds ratios (OR) and 95% confidence intervals (CI) were used to calculate the risk This meta-analysis was carried out by utilizing CMA software. Stratified analysis by ethnicity revealed that both IL-12B rs3212227 and IL-6 rs1800795 polymorphisms were associated with risk of cervical cancer in Asian women. Conclusions: Our pooled data revealed that the IL-12B rs3212227 and IL-6 rs1800795 polymorphisms may be used to identify individuals at high risk of cervical cancer in Asian women
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