Abstract
The self-assembly of two lipophilic dinucleoside molecules that have a common structure, comprising a bent “Z-shaped” central block substituted at the edges with complementary G and C nucleobases, are studied in this work by a combination of 1D and 2D NMR experiments, as well as by absorption, fluorescence and circular dichroism measurements as a function of the temperature and the concentration. Watson-Crick pairing affords cyclic tetramer G:C H-bound species that are less stable than those formed by related linear dinucleosides and that, in principle, due to the unusual monomer geometry, can establish an equilibrium between different conformations with the shape of a square and a rhomb.
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