Abstract
Luminescent inorganic lead halide perovskite nanoparticles lack stability in aqueous solutions, limiting their application to optical sensors. Here, hybrid CsPbBr3-loaded MIP nanogels were developed with enhanced stability in aqueous media. Multifunctional MIP nanogels with antioxidant function and hydrophobic cavities were synthesized from HEMA derivatives in the presence of roxithromycin as a template. The CsPbBr3 nanoparticles were loaded into pre-synthesized MIP nanogels via in-situ synthesis with a size distribution of 200 nm. The developed CsPbBr3-nanogel exhibits excellent stability to air/moisture and enhanced stability toward an aqueous solvent. The developed CsPbBr3-loaded MIP nanogels showed a selective and sensitive detection of ROX with a limit of detection calculated to be 1.7 × 10–5 μg/mL (20.6 pM). The developed CsPbBr3-loaded MIP antioxidant-nanogels were evaluated on practical application for the quantitative determination of ROX antibiotic in animal-derived food products with excellent analytical performance. The detection of ROX in animal-derived food products showed good recovery results, making them an ideal candidate for sensing ROX.
Highlights
Luminescent inorganic lead halide perovskite nanoparticles lack stability in aqueous solutions, limiting their application to optical sensors
ROX is rapidly absorbed, has a long half-life of elimination, and has excellent biological activity against Streptococcus, Staphylococcus aureus, Listeria, and Corynebacterium b acteria[26]. These advantages of ROX and other macrolides make them attractive in veterinary practice for use in the prevention and treatment of bacterial pathogens, abusive and unsafe use of macrolides antibiotics in farms can lead to the accumulation of macrolides and their residues in food products derived from animals, thereby causing allergic reactions or toxic effects on c onsumers[27]
To develop multifunctional molecularly imprinted polymer (MIP) nanogels that can enhance the stability of CsPbBr3 perovskites toward water and oxygen, three HEMA derivatives were synthesized
Summary
Luminescent inorganic lead halide perovskite nanoparticles lack stability in aqueous solutions, limiting their application to optical sensors. Inorganic and hybrid lead halide perovskites have drawn much interest from the scientific research community owing to their outstanding electrical and optical properties (e.g., high photoluminescence quantum yield and narrow emitting bands)[1–3] These types of materials have good compositional flexibility by various combinations of ions entering the crystal structure or by surface modification, the light emission spectral region can be adjusted in a large spectral wavelength region, and the preparation costs are relatively low[4,5]. ROX is rapidly absorbed, has a long half-life of elimination, and has excellent biological activity against Streptococcus, Staphylococcus aureus, Listeria, and Corynebacterium b acteria[26] These advantages of ROX and other macrolides make them attractive in veterinary practice for use in the prevention and treatment of bacterial pathogens, abusive and unsafe use of macrolides antibiotics in farms can lead to the accumulation of macrolides and their residues in food products derived from animals, thereby causing allergic reactions or toxic effects on c onsumers[27]. Mass spectrometry techniques are selective and sensitive; they require complicated sample pretreatment, expensive instrumentations, and well-trained personnel
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