Abstract
Recently, numerous scientific articles related to water soluble chitosan (WSC) have been released. Since the solubility of chitosan is restricted to acidic media, and there is an increasing demand against to the derivative of the chitosan polymer, which is mainly to obtain a material both having solubility in aqueous media and also being chitosan property. One of the benefits of synthesis of water soluble chitosan is to obtain a water soluble polymer is easily miscible with a variety of compounds in aqueous solutions. In this review, water soluble chitosan derivatives are principally examined in terms of their biological and other applications. Biological activities of WSC derivatives are analyzed in the sense of antioxidant, antimicrobial and anticancer activity, respectively. Thereby, the collected data may be useful to compare novel synthesized water soluble chitosan derivatives with alternative structures.
Highlights
Chitosan is a linear polysaccharide composed of β-(1-4)-linked 2-amino-2-deoxy-D-glucose and 2-acetamido-2-deoxy-D-glucose units
The findings suggested that mPEg-CS1 could be used in the treatment of liver injury that are linked with a high antioxidant activity [49]
Since this biopolymer is tended to dissolve in acidic media such as acetic, lactic and formic acids, its applications are limited due to many compounds are not soluble in acidic medium
Summary
Chitosan is a linear polysaccharide composed of β-(1-4)-linked 2-amino-2-deoxy-D-glucose and 2-acetamido-2-deoxy-D-glucose units. Adding water soluble functional groups on chitosan's back bone, converts the polymer in an expedient form for many biological applications such as being antioxidant [12], antimicrobial [13], and anticancer agent [14]. Many studies investigated the antioxidant activity of water soluble chitosan derivatives that even in pure forms or incorporated with any other compounds [37,38,39,40,41]. The antitumor activity of WSC was studied in the tumor cells in the mice after the preparation of water soluble low molecular weight chitosan the enzymatic hydrolysis with efficient hemicellulase.
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