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ARTICLESWarfarin resistance in the ratJG Pool, RA O'Reilly, LJ Schneiderman, and M AlexanderJG Pool, RA O'Reilly, LJ Schneiderman, and M AlexanderPublished Online:01 Sep 1968https://doi.org/10.1152/ajplegacy.1968.215.3.627MoreSectionsPDF (975 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByThe plasma half-lives of the enantiomers of warfarin in warfarin-resistant and warfarin-susceptible rats12 April 2011 | Journal of Pharmacy and Pharmacology, Vol. 24, No. 8Warfarin resistance test and polymorphism screening in the VKORC1 gene in Rattus flavipectus24 September 2010 | Journal of Pest Science, Vol. 84, No. 1Differential expression of cytochrome P450 genes between bromadiolone-resistant and anticoagulant-susceptible Norway rats: a possible role for pharmacokinetics in bromadiolone resistance1 January 2008 | Pest Management Science, Vol. 64, No. 3Biochemical basis of warfarin and bromadiolone resistance in the house mouse, Mus musculus domesticusBiochemical Pharmacology, Vol. 47, No. 4The Value of Plasma-Warfarin MeasurementVitamin K epoxide and quinone reductase activitiesBiochemical Pharmacology, Vol. 40, No. 5Tissue distribution and warfarin sensitivity of vitamin K epoxide reductaseBiochemical Pharmacology, Vol. 37, No. 5A comparison of warfarin resistance and liver microsomal vitamin K epoxide reductase activity in ratsBiochimica et Biophysica Acta (BBA) - General Subjects, Vol. 840, No. 1Relationship of dithiothreitol-dependent microsomal vitamin K quinone and vitamin K epoxide reductases Inhibition of epoxide reduction by vitamin K quinoneBiochimica et Biophysica Acta (BBA) - General Subjects, Vol. 798, No. 1Evidence that warfarin anticoagulant action involves two distinct reductase activities.Journal of Biological Chemistry, Vol. 257, No. 19Vitamin KThe vitamin K requirements of wild brown rats (Rattus norvegicus) resistant to warfarinComparative Biochemistry and Physiology Part A: Physiology, Vol. 66, No. 1Warfarin-Resistance Genotype Determination in the Norway Rat, Rattus Norvegicus1 July 1979 | Laboratory Animals, Vol. 13, No. 3Taxonomy and GeneticsGLC Determination of Warfarin in Human PlasmaJournal of Pharmaceutical Sciences, Vol. 67, No. 1Pharmacogenetics21 June 2005Vitamin KVitamin K and γ-Carboxyglutamate BiosynthesisIsolation of a warfarin binding protein from liver endoplasmic reticulum of Sprague-Dawley and warfarin-resistant rats.Journal of Biological Chemistry, Vol. 252, No. 18Inheritance of resistance to warfarin in Rattus rattus L.Journal of Stored Products Research, Vol. 12, No. 4Inheritance of Scottish-type resistance to warfarin in the Norway rat14 April 2009 | Genetical Research, Vol. 28, No. 3REFERENCESStudies of the microsomal drug metabolism system in warfarin-resistant and -susceptible ratsBiochemical Pharmacology, Vol. 24, No. 6New Concepts Relating to the Mode of Action of Vitamin KGLC Determination of Plasma Levels of WarfarinJournal of Pharmaceutical Sciences, Vol. 63, No. 11Liquid Chromatographic Assay of Warfarin: Similarity of Warfarin Half-Lives in Human SubjectsScience, Vol. 184, No. 4135Anticoagulant-Resistant Rats: Possible Control by the Use of the Chloro Analog of Vitamin K 1Science, Vol. 180, No. 4087Mechanism of warfarin resistance. Warfarin and the metabolism of vitamin K11 May 2002 | Biochemistry, Vol. 12, No. 9Vitamin K and warfarinThe American Journal of Medicine, Vol. 53, No. 3Warfarin and the Inhibition of Vitamin K Activity by an Oxide MetaboliteNature, Vol. 237, No. 5349DT DIAPHORASE — REACTION MECHANISM AND METABOLIC FUNCTIONA Study of the DT-Diaphorase Activity of Warfarin-Resistant RatsEuropean Journal of Biochemistry, Vol. 25, No. 1Studies on the site of action of dicumarol on prothrombin biosynthesisBiochimica et Biophysica Acta (BBA) - General Subjects, Vol. 237, No. 2Effect of dicumarol upon protein synthesis in the ratBiochemical Pharmacology, Vol. 20, No. 4Warfarin-Resistant Rats — Some Practical Aspects6 July 2009 | PANS Pest Articles & News Summaries, Vol. 17, No. 1Comparison of Plasma Concentrations of Warfarin Measured by Both Simple Extraction and TLC MethodsJournal of Pharmaceutical Sciences, Vol. 59, No. 11Genetic control of the response to coumarin anticoagulants in the ratHumangenetik, Vol. 9, No. 3Linkages between Genes for Coat Colour and Resistance to Warfarin in Rattus norvegicusNature, Vol. 224, No. 5216 More from this issue > Volume 215Issue 3September 1968Pages 627-631 Copyright & PermissionsCopyright © 1968 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1968.215.3.627PubMed5671000History Published online 1 September 1968 Published in print 1 September 1968 Metrics

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