Abstract
ized linear inverse source estimates of cortical current density. Determination of the priors in the resolution of the linear inverse problem was performed with the use of information from the hemodynamic responses of the cortical areas as revealed by block-designed (strength of activated voxels) fMRI. We estimate functional cortical connectivity by computing the directed transfer function (DTF) and the Partial Directed Coherence (PDC) on the estimated cortical current density waveforms in regions of interest (ROIs) on the modeled cortical mantle. Furthermore, this method allows to detect changes in the time course of information flow between cortical regions in different frequency bands. Results: The reliability of these techniques was further demonstrated by simulation studies and the elaboration of high-resolution EEG and fMRI signals collected during different cognitive and motor tasks in healthy subjects. Discussion: Multimodal integration of high resolution EEG and fMRI data offers a significant aid for the study of the ‘‘when’’ , ‘‘where’’, and ‘‘how’’ in the cortical brain regions.
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