Abstract
A variety of factors are involved in the formation of lesions induced by nonsteroidal anti-inflammatory drugs(NSAIDs) in the small intestine, considered unaffected by acid, including intestinal flora, bile, and mucous, and as yet there are no established preventive or therapeutic measures.Geranylgeranylacetone(GGA), a gastric mucosal protective agent, is used in the treatment of gastritis and gastric ulcers. It also induces heat shock proteins, and has been shown to inhibit NSAID-induced gastric mucosal injury in humans and small intestinal injury in mice.
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