Abstract
Background: The vulvar intraepithelial neoplasia is divided into two groups: usual type and differentiated type. The differentiated vulvar intraepithelial neoplasia which is frequently seen together with the invasive squamous cell carcinoma can be confused with some benign lesions. To analyse p16, p53, and Ki-67 expression characteristics of different histological types of invasive squamous cell carcinoma of the vulva and vulvar intraepithelial neoplasia is aimed in this study. Methods: In this study, immunohistochemical analysis of 18 vulvectomy cases with p16, p53, and Ki-67 was performed. Results: Of 18 patient who underwent vulvectomy, 9 had invasive squamous cell carcinoma and 9 vulvar intraepithelial neoplasia. 3 additional vulvar intraepithelial neoplasia lesions were found accompanying the invasive squamous cell carcinomas. Mean Ki-67 PI was 32,3% in usual type (human papilloma virus-related) vulvar intraepithelial neoplasia cases (n:9), and 26,4% in differentiated vulvar intraepithelial neoplasia cases (n:3)(p>0,05). Mean p16 staining degree was 2,6 for usual type vulvar intraepithelial neoplasias. No p53 expression was present in squamous cell hyperplasia or lichen sclerosis lesions. Conclusions: Ki-67 PI does not have significant value in recognizing vulvar intraepithelial neoplasia usual type and differentiated vulvar intraepithelial neoplasia. p53 positivity can be of value in distinguishing especially differentiated type vulvar intraepithelial neoplasia from benign lesions.
Highlights
The vulvar intraepithelial neoplasia is divided into two groups: usual type and differentiated type
Vulvar squamous cell carcinomas have been grouped into 3 histopathologic types as basaloid, warty and keratinizing, and vulvar intraepithelial neoplasia (VIN) were evaluated according to 2004 ISSVD terminology (6)
While Ki-67 proliferation index (PI) is determined in full thickness of epithelium and diffusely in VIN cases of warty and basaloid characteristics, it has no diagnostic value in differentiated VIN cases
Summary
The vulvar intraepithelial neoplasia is divided into two groups: usual type and differentiated type. To analyse p16, p53, and Ki-67 expression characteristics of different histological types of invasive squamous cell carcinoma of the vulva and vulvar intraepithelial neoplasia is aimed in this study. VIN terminology was modified in 2004 by The International Society for the Study of Vulvovaginal Disease (ISSVD), and was mainly divided into two groups: VIN usual type and VIN differentiated (simplex) type. These terms account for VIN 2 and VIN 3 in the older terminology, and the term VIN 1 has not been used anymore [5,6,7,8]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
