Abstract
Abstract Purpose: HOXB7 is a gene of HOX gene family, which has been found to play a role in cancer cell proliferation, angiogenesis, and invasion. Due to its potential responsibility in cancer aggression, the main
Highlights
Renal cell carcinoma (RCC) encompasses a heterogeneous group of cancers derived from renal tubular epithelial cells and is among the 10 most common cancers worldwide [1]
We found that HOXB7 was expressed in the Renal cell carcinoma tissues and related to the Gleason Scores, pathological grade and metastasis
Immunohistochemistry showed that positive staining of was frequently located in the cytoplasm of cancer cells in Renal cell carcinoma tissues (56/60, 93.3%)
Summary
Renal cell carcinoma (RCC) encompasses a heterogeneous group of cancers derived from renal tubular epithelial cells and is among the 10 most common cancers worldwide [1]. Localized RCC can be treated with partial or radical nephrectomy (removal of the kidney) [2], ablation (destruction of the malignant tissue with heat or cold) [3], or active surveillance (monitoring of tumor growth with periodic radiographic studies) [4]. Despite nephrectomy with curative intent, ~30% of patients with RCC with localized disease eventually develop metastases, which require systemic therapies and are associated with high mortality. Early diagnosis is very important to Renal cell carcinoma patients, for early diagnosis helps to guide the medical strategy for the step. There are no effective methods to predict the prognosis in Renal cell carcinoma. New tools should be developed for diagnosis and predicting prognosis for early stages of Renal cell carcinoma
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