Vulnerabilidade da doença aterosclerótica de carótidas: do laboratório à sala de cirurgia - parte 2

Luciano Cabral Albuquerque,Aluísio Antunes Maciel,Henrique Staub,Luis Eduardo Rohde,Maurício Friedrich,Luciane Barreneche Narvaes,João Rubião Hoefel Filho,Maurício Anes

doi:10.1590/s0102-76382006000300003

Abstract

1 - Member of the Brazilian Society of Cardiovascular Surgery. Masterin Cardiology by the Federal University of RS. Cardiovascular Surgeonof Hospital Sao Lucas da PUCRS.2 - Student of post graduation course in Cardiology at the FederalUniversity of RS Cardiovascular Surgeon of Hospital Sao Lucas daPUCRS.3 - Head of Imaging Diagnostic Center of Hospital Sao Lucas daPUCRS. Assistant Professor of Pathology Department of MedicalSchool of PUCRS.4 - Doctor of Magnetic Resonance and Computed TomographyLaboratory of Hospital Sao Lucas da PUCRS.5 - Pathologist of Hospital Sao Lucas da PUCRS.6 - PhD in rheumatology of Catholic Pontifical University of RioGrande do Sul. Assistant Professor of Internal Medicine Departmentof Medical School of PUCRS. Rheumatologist of Hospital Sao Lucasda PUCRS.7 - PhD in neurosciences by Catholic Pontifical University of RioGrande do Sul. Head of Neurovascular Diseases Program of theHospital Sao Lucas da PUCRS.8 - PhD in Cardiology by the Federal University of RS. AdjunctProfessor of Medicinal Internal Department of Medical School ofPUCRS. Professor of post graduation course in Cardiology andCardiovascular Sciences of Federal University of RS. Cardiologist andEchocardiographist of the Cardiology Service of the Hospital deClinicas de Porto Alegre.Work carried out in the Hospital Sao Lucas of Catholic PontificalUniversity of Rio Grande do Sul and in the post graduation course inCardiology and Cardiovascular Sciences of the Federal University ofRio Grande do Sul, Porto Alegre, RS.Correspondence address:Luciano Cabral Albuquerque. Centro Clinico do Hospital da PUCRS.Av. Ipiranga 6690, conj. 615. Porto Alegre, RS. ECP 90610-000.Phone/Fax: (0XX51) 3336-8190.E-mail: alb.23@terra.com.br

Highlights

Atherosclerosis is a chronic predominantly silent process in which local and systemic factors interact to reduce or delay clinical events
Waddington et al [14] studying the oxidation of fatty acids in carotid artery disease, did not manage to demonstrate a direct correlation with clinical instability, Nishi et al [15] observed that high levels of oxidized anti-LDL antibodies are associated with greater macrophage infiltration in a histological analysis of 44 specimens from carotid endarterectomies suggesting that this marker may confirm plaque vulnerability
Atherosclerosis of carotid artery has acquired great epidemiological relevance due to its high prevalence in the aging population and as it is a frequent cause of strokes

Summary

SPECIAL ARTICLE

Vulnerabilidade da doença aterosclerótica de carótidas: do laboratório à sala de cirurgia – Parte 2. 2 - Student of post graduation course in Cardiology at the Federal University of RS Cardiovascular Surgeon of Hospital São Lucas da PUCRS. 7 - PhD in neurosciences by Catholic Pontifical University of Rio Grande do Sul. Head of Neurovascular Diseases Program of the Hospital São Lucas da PUCRS. Work carried out in the Hospital São Lucas of Catholic Pontifical University of Rio Grande do Sul and in the post graduation course in Cardiology and Cardiovascular Sciences of the Federal University of Rio Grande do Sul, Porto Alegre, RS. ALBUQUERQUE, LC ET AL - Vulnerability of atherosclerotic carotid disease: from laboratory to operating room – Part 2

INTRODUCTION

Morphological aspects of atheroma in carotid artery disease

High resolution magnetic resonance

Findings

CONCLUSION