Abstract
Objective To evaluate early occult brain damage by diffusion tensor imaging in patients with typeⅡdiabetes mellitus. Methods High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MRI images and diffusion tensor imaging were obtained from 16 patients with typeⅡdiabetes mellitus (T2DM) and 16 normal controls (NC).Average apparent diffusion coefficient (ADC) map and fractional anisotropy (FA) map were calculated and analyzed with voxelbased analysis.Analysis of covariance was performed to compare ADC and FA between T2DM and NC. Results Increased ADC values of gray matter were demonstrated in right superior temporal gyrus,middle frontal gyrus,anterior cingulate gyrus,middle cingulate gyrus,inferior occipital gyrus,and left lingual gyrus,operculum orbitale,fusiform gyrus and parahippocampal gyrus in T2DM (voxel numbers in clusters were 176—3125,P<0.01).And increased ADC values of white matter were demonstrated in the regions of right middle temporal lobe,linual lobe,middle frontal lobe,calcarine gyrus,superior parietal lobe,and left operculum orbitale in T2DM patients compared with NC (voxel numbers in clusters were 200—781,P<0.01).Decreased FA values of gray matter were mainly located in left thalamus,bilateral caudate nuclei and right cuneus in T2DM (voxel numbers in clusters were 210—1402,P<0.01).Decreased FA values of white matter were demonstrated in the regions of right cuneus and the body of corpus callosum in T2DM (voxel numbers in clusters were 206,253,P<0.01). Conclusions The occult brain damage is demonstrated as increased ADC values and decreased FA values in regional brain parenchyma in typeⅡdiabetes mellitus.Voxel-based analysis of diffusion tensor indices may be a simple and effective tool for the evaluation of occult brain damage in typeⅡdiabetes mellitus. Key words: Diabetes mellitus,typeⅡ; Brain; Diffusion magnetic resonance imaging
Published Version
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