Volumetric properties of the nucleosides adenosine, cytidine, and uridine in aqueous solution at T = 298.15 K and p = (10 to 120) MPa

Abstract

Sound speeds have been measured for aqueous solutions of the nucleosides adenosine, cytidine, and uridine at T=298.15K and at the pressures p=(10, 20, 40, 60, 80, 100, and 120)MPa. Using methods described in previous work, these sound speeds were used to derive the partial molar volumes at infinite dilution, V2o, the partial molar isentropic compressions at infinite dilution, KS,2o, and the partial molar isothermal compressions at infinite dilution, KT,2o{KT,2o=-(∂V2o/∂p)T}, for the nucleosides in aqueous solution at elevated pressures. The V2o and KT,2o results were rationalized in terms of the likely solute–water interactions. The V2o results were also critically compared with those calculated using the revised Helgeson–Kirkham–Flowers (HKF) equation of state.