Volumetric Properties at High Pressures of the Nucleosides Inosine, 2′-Deoxyinosine, and 2′-Deoxyguanosine and the Volumetric Properties of Guanosine Derived Using Group Additivity Methods

Abstract

Sound speeds have been measured for aqueous solutions of the nucleosides inosine, 2′-deoxyinosine, and 2′-deoxyguanosine at T = 298.15 K and at the pressures p = (0.1, 10, 20, 40, 60, 80, and 100) MPa. Using methods described in previous work, these sound speeds were used to derive the partial molar volumes at infinite dilution, V2o, the partial molar isentropic compressions at infinite dilution, KS,2o, and the partial molar isothermal compressions at infinite dilution, KT,2o {KT,2o = −(∂V2o/∂p)T}, for the nucleosides in aqueous solution at the elevated pressures. A semiempirical model was used to rationalize the KT,2o results in terms of changes in hydration of the solutes as a function of pressure. Group additivity methods were used to derive values of V2o and KT,2o over the pressure range p = (10 to 100) MPa for the sparingly soluble nucleoside guanosine.