Abstract
Eukaryotic cells finely control their size and, typically, nuclear volume scales with cell volume. The corresponding nuclear to cell volume ratio (N/C ratio) is narrowly distributed for a given cell-type and deviation from this distribution is a well-known hallmark of senescence or cancer. However, mainly for the lack of methods to simultaneously measure both cellular and nuclear volumes, the mechanisms underlying their size regulation and coupling remain unclear.To overcome this limitation, we developed an imaging method for measuring in real time both cytoplasmic and nuclear volumes of living cells.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
