Abstract
The electrochemical behaviour of tamoxifen has been investigated at gold electrode by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and squarewave voltammetric techniques. The dependence of current and potential on pH, concentration, scan rate, nature of solvent, surfactants and different surfactant concentration is investigated. Tamoxifen is oxidized in a single two-electron, irreversible and diffusion-controlled wave. Linear calibration plots are obtained over the concentration range 1.0-5.0 and 1.0-6.0 µgmL(-1) in 1.0 M KCl and Britton Robinson buffers (pH 2.51) respectively. The procedure has been applied to the assay of the drug in tablet form with mean percentage recoveries of 99.98%. The suggested method can be successfully applied to the determination of tamoxifen in different drug formulations.
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