Abstract
Cyclic voltammetry was used to study the electrochemical behavior of tinidazole at carbon paste electrode. Tinidazole showed an irreversible reduction peak at about -440 mV. The differential pulse voltammetric peak current of tinidazole showed linear dependence on concentration in the range 5.0-200 μM with LOD and LOQ of 5.1 10 -7 and 1.7 10 -6 μM, respectively. Relative to most of the reported works on the determination of tinidazole, the developed method using carbon paste electrode which is an environmentally friendly, cheap, and simple working electrode exhibited linear dependence of peak current on concentration in the lower concentration region with relatively low LOD. Excellent recovery results with low % RSD for spiked standard tinidazole in tablet samples showed the potential applicability of the developed method for the determination of tinidazole in real samples. KEY WORDS : Carbon paste electrode, Differential pulse voltammetry, Tinidazole, Pharmaceutical tablets Bull. Chem. Soc. Ethiop. 2016 , 30(1), 1-12. DOI: http://dx.doi.org/10.4314/bcse.v30i1.1
Highlights
Compounds derived from nitroimidazole ring system (Table 1) form the basis of several important drugs exhibiting novel biological activities [1, 2]
The biological activity of nitroimidazole derivatives is dependent upon the nitro group reduction process due to the formation of active intermediate species that interact with DNA causing biochemical damage [3,4,5]
Tinidazole (1-(2-(ethylsulfonyl)ethyl)2-methyl-5-nitro-1H-imidazole) which is one of the nitroimidazole derivatives has been used as an antiprotozoal agent for many years in the treatment of infestations caused by Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia [6, 7]
Summary
Compounds derived from nitroimidazole ring system (Table 1) form the basis of several important drugs exhibiting novel biological activities [1, 2]. The biological activity of nitroimidazole derivatives is dependent upon the nitro group reduction process due to the formation of active intermediate species that interact with DNA causing biochemical damage [3,4,5]. Tinidazole (1-(2-(ethylsulfonyl)ethyl)2-methyl-5-nitro-1H-imidazole) which is one of the nitroimidazole derivatives has been used as an antiprotozoal agent for many years in the treatment of infestations caused by Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia [6, 7]. Tinidazole (TNZ) has been used against anaerobic bacterial infections for prophylaxis in patients undergoing cystectomy or colorectal surgery and as a radio sensitizer [8, 9]. TNZ, in combination with amino penicillin, can be used to treat children infected with Helicobacter pylori [10]
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