Abstract

Purpose: A new sensitive sensor was fabricated for the determination of ivabradine hydrochloride (IH) based on modification with multiwalled carbon nanotubes using sodium dodecyl sulfate as micellar medium to increase the sensitivity. Methods: The electrochemical behavior of IH was studied in Britton-Robinson buffer (pH: 2.0-11.0) using cyclic and differential pulse voltammetry. Results: The voltammetric response was linear over the range of 3.984 x 10-6-3.475 x 10-5 mol L-1. The limits of detection and quantification were found to be 5.160 x 10-7 and 1.720 x 10-6 mol L-1, respectively. Conclusion: This method is suitable for determination of IH in tablets and plasma.

Highlights

  • Ivabradine HCl (IH) is used to reduce the heart rate through inhibition of the pacemaker current (If)

  • Multiwalled carbon nanotubes (MWNTs) modified electrodes have plentiful characteristics compared with bare electrode according to their unrivaled properties

  • This study aims to determine IH at multiwalled carbon nanotubes modified carbon paste electrode (MWCNTCPE) utilizing voltammetric method based on the electrochemical oxidation of IH

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Summary

Introduction

Ivabradine HCl (IH) is used to reduce the heart rate through inhibition of the pacemaker current (If). Multiwalled carbon nanotubes (MWNTs) modified electrodes have plentiful characteristics compared with bare electrode according to their unrivaled properties. Nanoparticles increase the number of active sites and the rate of mass transport to the electrode surface.[21,22,23,24] This study aims to determine IH at multiwalled carbon nanotubes modified carbon paste electrode (MWCNTCPE) utilizing voltammetric method based on the electrochemical oxidation of IH

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