Abstract
The redox characteristics of the drug Bicalutamide at a glassy-carbon electrode (GCE) was investigated for the first time in aqueous media by differential-pulse voltammetry (DPV) and cyclic voltammetry (CV). In Britton-Robinson (BR) buffer of pH 2.0-10.0, an irreversible and diffusion-controlled reduction voltagram were developed. The dependence of the CV response of the developed cathodic peak on the sweep rate ( �) and on depolarizer concentration was typical electrode-coupled chemical reaction mechanism (EC) in which an irreversible reaction is interposed between the charges. In BR buffer of pH 6 - 7, a well defined cathodic peak was developed and the plot of peak current height of the DPV against Bicalutamide concentration at this peak potential was linear in the range 1×10 �8 - 2.6 ×10 �5 M with lower limits of detection (LOD) and quantization (LOQ) of 8 x 10 -8 M and 1 ×10 �7 M, with good selectivity and sensitivity. A relative standard deviation (RSD) for Bicalutamide at a concentration of 4.5×10 �5 M was 2.48% (n=6). The proposed method was successfully applied to Bicalutamide determination in pharmaceutical samples and results are very good correlations with previously reported methods.
Highlights
Cyano-3-(trifluoromethyl) phenyl]-3-[(4-fluorophenyl) sulfonyl]-2-hydroxy-2-methyl-propanamide, under the trade name of Casodex [1,2,3]
When CASODEX is combined with luteinizing hormone-releasing hormone (LHRH) analogue therapy, the suppression of serum testosterone induced by the LHRH analogue is not affected
3.1 Electrochemical Behavior of Bicalutamide Preliminary studies on the electrochemical behavior of Bicalutamide in DMF with Tetra Butyl Ammonium per chlorate as supporting electrolyte at a Glassy Carbon electrode by use of Cyclic Voltammetry have shown that the drug has well defined Reduction and Oxidation peak developed in the potential range –2.0 V to +1.80V relative to SCE reference electrode
Summary
Cyano-3-(trifluoromethyl) phenyl]-3-[(4-fluorophenyl) sulfonyl]-2-hydroxy-2-methyl-propanamide, under the trade name of Casodex [1,2,3]. 3.1 Electrochemical Behavior of Bicalutamide Preliminary studies on the electrochemical behavior of Bicalutamide in DMF with Tetra Butyl Ammonium per chlorate as supporting electrolyte at a Glassy Carbon electrode by use of Cyclic Voltammetry have shown that the drug has well defined Reduction and Oxidation peak developed in the potential range –2.0 V to +1.80V relative to SCE reference electrode.
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