Abstract
Abstract A simple sensitive voltammetric method to detect and to determine a nano level anthranilic acid derivative, mefenamic acid has been developed using different voltammetric techniques in pH 5.0 phosphate buffer solutions with ionic strength 0.2M. An enhancement of oxidation peak current for an analyte on the modified paste was observed followed by characterization with atomic mass spectroscopy analysis. The control of various parameters on the drug oxidation current like accumulation time, amount of modifier, pH, scan rate, and concentration was also evaluated. The analytical applications were studied by square wave voltammetry technique. A suitable electro-oxidation mechanism for mefenamic acid at nanoparticles silver-doped titanium dioxide modified carbon paste electrode was proposed. The oxidation peak currents of mefenamic acid concentration was studied using square wave voltammetry technique in the range 1.0 x 10-8 to 3.0 x 10-6 M with a lower detection limit 1.94 nM compared to earlier reported practice. The modified sensor showed an excellent physiological feature, large surface area, remarkable stability, reproducibility by simple preparation process. The proposed method was successfully employed for the determination of mefenamic acid in pharmaceutical and biological samples with good recovery values.
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