Abstract
SUMMARY Detecting exhaled volatile organic compounds (VOCs) that are associated with lung cancer (LC) has realistic potential for becoming an integral part of population-based LC screening and monitoring in the near future. Here, we review the main three approaches for profiling VOCs in LC patients and their advantages and pitfalls: first, mass spectrometry techniques for the identification and/or quantification of a wide variety of separate breath VOCs; second, canines that are trained to sniff out LC; and third, cross-reactive chemical sensors in combination with statistical methods for identifying disease-specific patterns. We estimate that the latter would be most suitable for clinical practice. In the short run, breath testing could provide a critically needed adjunct method for detecting nodule malignancy with high specificity during low-dose computed tomography screening. In the long run, breath testing holds potential for entirely revolutionizing LC screening, diagnosis and management.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.