Vitamin D3 status and insulin resistance in Iraqi patients with osteoarthritis disease in Baghdad governorate-Iraq

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Musculoskeletal disability and pain are the most symptoms common results of osteoarthritis .The Iraqi capital region Baghdad registers some of the lowest serum vitamin D3 concentrations, which associated with osteoarthritis disease. The aim of this study to found relationship between levels of vitamin D3 and knee pain in knee osteoarthritis patients in Iraq. Secondly, to determine if there is a correlation of Vitamin D3 and each of BMI, Thyroid hormones levels, insulin and HOMA-IR. Eighty participant of osteoarthritis patients were depended in this study (39 male, 41 female), compared with 30 control (15 male, 15 female). The study was approved by the National Diabetes center at Mustansiriyah University, in Baghdad-Iraq. Serum levels of HbA1c and HOMA-IR were statistically higher in osteoarthritis patients than in healthy controls , there was no significant of TT3, TT4 and TSH in osteoarthritis patients when compared with control ,while a significant increase of TSH in male osteoarthritis patients but not significant of TSH in female osteoarthritis patients when compared with control group. Vitamin D3 was significantly lower in osteoarthritis patients when compared to controls. No significant correlation was found between the serum levels of vitamin D3 and all parameters, except a significant positive correlation was found with the serum levels of triglyceride. A significant positive correlation was found between the serum levels of vitamin D3 with FBG and also BMI in male osteoarthritis patients with normal weight, while a negative correlation was found between the serum levels of vitamin D3 and total cholesterol in Obese male patients. According to our data, it seems that the decreased serum levels of vitamin D3 may play a major role in the pathogenesis and pain of osteoarthritis . Additionally, based on the negative correlation between serum levels of vitamin D3 and BMI in this study, may be one of the reasons of pain and osteoarthritis complications. The doses of 50000 IU/week may be necessary to reach a desirable vitamin D3 level of 50-70 ng/ml. Studies assessing the effect of such doses of vitamin D on major results, but they are needed to confirm their long term safety.