Abstract
A clinical comparison of three vitamin D3 analogues and metabolites in the topical treatment of scalp psoriasis is reported and the characteristics of the three agents are discussed. Three groups of patients suffering from chronic plaque psoriasis of the scalp were treated with calcitriol ointment 3 μg/g twice daily, tacalcitol ointment 4 μg/g once daily or calcipotriol ointment 50 μg/g twice daily. Total clearance was achieved in 45.0%, 35.2% and 17.6% of the patients, respectively, and significant improvement was achieved in 35.0%, 29.4% and 35.3%, respectively, with no severe side-effects other than local irritation. We regard this group of antipsoriatic agents as useful for the treatment of lesions localized on the scalp because of their efficacy (comparable with topical corticosteroids), safety (lack of atrophogenic action) and tolerability (ease of application, especially tacalcitol). The additional advantage is their dose-dependent influence on hair follicle and fibre growth by binding vitamin D receptors localized in the hair follicle structure.
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