VITAMIN D SUFFICIENCY IN PATIENTS WITH NON-DEVELOPING PREGNANCIES

Abstract

The aim of the study was to study vitamin D sufficiency in patients with non-developing pregnancies. The study included 32 women with the diagnosis "non-developing pregnancy" and 30 patients with a gestation period of 7–10 weeks. The women of both groups had the level of vitamin D determined by the content of 25 (OH)D in blood serum (an enzyme immunoassay was performed with a kit manufactured by BIOMEDICAGRUPPE (Germany)). Vitamin 25 (OH)D level was evaluated according to the clinical recommendations of the Russian Association of Endocrinologists (2015): physiological level–30-35 ng / ml and more, insufficient provision –10-20 ng/ml, deficient state − 10 ng/ml and less. It was found that there were more extragenital diseases in women with non-developing pregnancy than in patients of the control group, and the obstetric and gynecological history was more burdened in women with non-developing pregnancies. A high somatic morbidity, gynecological diseases and curettage of uterine cavity in the anamnesis negatively affect the development of the embryo and fetus. At this, it should be noted that women with non-developing pregnancies were found to be deficient in 25(OH)D, whereas in pregnant women the vitamin D content corresponds to the physiological values. In this regard, taking vitamin D supplements may be recommended for women when planning pregnancy and during pregnancy, especially in its early stages.