Vitamin D Status in Children with Recurrent Wheeze

Abstract

Background it has been shown that low serum 25-hydroxyvitamin D concentration was associated with a higher risk of upper and lower respiratory infections in children Aim to evaluate vitamin D concentration and selected biochemical markers in infants and children with recurrent wheeze. Methods a case-control study has been carried out to measure serum vitamin D concentration; on 33 patients with recurrent wheeze, their ages ranged from 4-60 months; over the period from the1stof March 2014 to the end of June 2014. Forty-two age and sex matched healthy children were selected as control group. List of investigation was measured by spectrophotometer as serum calcium, phosphorus, alkaline phosphatase and 25-OH vitamin. Result Frequency of breast feeding in the first two years of life was low in wheezy children and significantly shorter duration of breast feeding less than 4 months in wheezy children than control group, P value 0.01. Vitamin D concentration was significantly low in children with recurrent wheeze than the control group; (21.69 ng/ml, 39.36 ng/ml) respectively with p-value 0.000 The severity of vitamin D deficiency was significant in children with recurrent wheeze, severe deficiency of vitamin D There is no significant relation observed between mean Vitamin D concentration and selected variables of infants and children with wheeze (p value >0.05) Conclusion vitamin D supplementation may be considered in infants and children with recurrent wheeze.