Abstract
Sufficient vitamin D levels are associated with reduced Helicobacter pylori infections, which can cause gastric carcinogenesis. We examined associations between vitamin D concentrations and gastric cancer (GC) prevalence in a Korean population. We analyzed data of 33,119 adults using serum 25-hydroxyvitamin D (25(OH)D) concentrations as a biomarker of vitamin D status. Participants were classified with GC if previously diagnosed as such by a physician. After controlling for age, sex and body mass index (model A), odds ratio (OR) for GC was 0.81 (95% confidence interval [CI]: 0.70, 0.95), with a 5-ng/mL increment in total 25(OH)D concentrations. In fully adjusted models (model B), the OR for GC was 0.84 (95% CI: 0.72, 0.98), with a 5-ng/mL increment in total vitamin D. Following the classification of vitamin D concentrations into three categories or for GC in model A was 0.52 (95% CI: 0.30, 0.92) comparing between higher (≥20 ng/mL) and lower (<12 ng/mL) total 25(OH)D concentrations. In model B OR for GC was 0.57 (95% CI: 0.32, 1.00) comparing between higher and lower total 25(OH)D concentrations. Our results suggested that high vitamin D concentration was associated with lower ORs of GC in Korean adults.
Highlights
Worldwide, gastric cancer (GC) ranks fifth in cancer incidence [1], with 1.3 million (1.2–1.4 million) incident cases of GC in 2015
Our results suggested that high vitamin D concentration was associated with lower odds ratio (OR) of GC in Korean adults
Males accounted for 51.0% of the study population, and the mean total vitamin D concentration was 17.5 (±0.10) ng/mL
Summary
Gastric cancer (GC) ranks fifth in cancer incidence [1], with 1.3 million (1.2–1.4 million) incident cases of GC in 2015. In Korea, GC ranks second in cancer incidence, and with a 35.8 per. 100,000 incidence rate in 2014 [2]. In a study of factors affecting GC, Ren et al reported that patients with sufficient vitamin D had a lower overall mortality than patients with vitamin D deficiency in GC patients [4]. An experimental study suggested that 1,25-(OH)D3 can induce apoptosis in GC cells, suggesting its use in cancer therapy [5]. A recent meta-analysis reported that sufficient vitamin D could be associated with a decrease in H
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