Abstract
ObjectiveThis study aimed to quantitatively summarize the evidence for VDR BsmI gene polymorphism and osteoporosis risk in postmenopausal women.Materials and methodsThe PubMed, EMBASE, Weipu, CNKI, and Wanfang databases were searched for eligible studies. Case-control studies containing available genotype frequencies of B/b were chosen, and odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association.Results4485 osteoporosis and 5490 controls were identified in our meta-analysis. In the stratified analysis, a significant association was observed between VDR BsmI gene polymorphism and osteoporosis susceptibility in Caucasians (additive model: OR = 0.809, 95% CI 0.678~0.965, p = 0.019; recessive model: OR = 0.736, 95% CI 0.568~0.955, p = 0.021; and co-dominant model: bb vs. BB OR = 0.701, 95% CI 0.511~0.962 p = 0.028), and we failed to find any significant relationship in Asians.ConclusionThe present meta-analysis suggests that VDR BsmI genotype is associated with increased risk of postmenopausal osteoporosis in Caucasians but not in Asians. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR BsmI polymorphism and osteoporosis in postmenopausal women.
Highlights
Osteoporosis, as a systemic bone disease characterized by decreased bone mineral density, micro-structure deterioration of bone tissue, and increased risk of bone fracture [1, 2], is commonly seen in postmenopausal females and aged males; about 30% of postmenopausal females suffer from osteoporosis [3]
In 1992, Morrison et al reported that bone mineral density and circulating osteocalcin levels may be affected by vitamin D receptor (VDR) BsmI polymorphism [8, 9]
In 1996, Berg et al reported for the first time that VDR BsmI polymorphism was associated with bone mineral density in postmenopausal females [11]
Summary
Osteoporosis, as a systemic bone disease characterized by decreased bone mineral density, micro-structure deterioration of bone tissue, and increased risk of bone fracture [1, 2], is commonly seen in postmenopausal females and aged males; about 30% of postmenopausal females suffer from osteoporosis [3]. In 1992, Morrison et al reported that bone mineral density and circulating osteocalcin levels may be affected by VDR BsmI polymorphism (rs1544410) [8, 9]. In 1996, Berg et al reported for the first time that VDR BsmI polymorphism was associated with bone mineral density in postmenopausal females [11]. Epidemiological investigations regarding the assessment of BsmI polymorphism and the susceptibility of postmenopausal osteoporosis have been widely reported. In a survey of the Thai population, VDR BsmI polymorphism did not seem to be associated with the risk of postmenopausal osteoporosis [12]. The meta-analysis was performed on the currently published eligible casecontrol studies combined with the previous research results, and the relationship between Bsm I polymorphism and the risk of osteoporosis in postmenopausal females was explored
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