Abstract
Objective: The aim of this study was to quantitatively summarize the evidence for VDR FokI gene polymorphism and osteoporosis risk in postmenopausal women. Materials and methods: Electronic search at PubMed, EMBASE, Weipu database, and Wanfang database was conducted to select studies. Case-control studies containing available genotype frequencies of F/f were chosen, and Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this revelance. Results: The case-control studies including 2199 osteoporosis cases and 2231 controls were identified. Overall meta-analysis indicated that individuals with the homozygous ff genotype had increased risk of osteoporosis(Recessive model: OR=1.551, 95% CI: 1.035~2.325,p=0.034).In the stratified analysis, individuals with the ff genotype in the Recessive model had increased risk of osteoporosis in Asian subjects(OR=2.644, 95% CI: 1.583~4.419,p= 0.000),but not in Caucasian subjects(OR= 1.288, 95%CI: 0.783~2.118, p = 0.318) and Mixed subjects (OR= 0.885, 95%CI: 0.686~1.141, p =0.346). A symmetric funnel plot, the Begg- test (P=0.094) suggested that lack of publication bias. The studies conducted in each of the defined number of osteoporosis—had no effect of the FokI polymorphism on osteoporosis except for the ff versus Ff+FF genotype comparison for osteoporosis subgroup. Conclusion: In conclusion, our meta-analysis suggests that VDR Fok I genotype is associated with increased risk of osteoporosis in Asian but not in caucasian. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR Fok I polymorphism and osteoporosis.
Highlights
Osteoporosis is a progressive bone disease that is characterised by a decrease in bone mass and density and that leads to an increased risk of fracture
Morrison’s study have shown that vitamin D receptor has been associated with Bone Mineral Density (BMD), which is the major determinant of osteoporosis risk [3,4]
The strength of association between vitamin D receptor gene (VDR) FokI gene and osteoporosis was accessed by calculating crude odds ratios (ORs) and 95% confidence intervals (CIs)
Summary
Osteoporosis is a progressive bone disease that is characterised by a decrease in bone mass and density and that leads to an increased risk of fracture. The bone mineral density (BMD) is reduced, bone microarchitecture deteriorates, and the amount and variety of proteins in bone are altered. Both environmental and genetic factors are the etiology of osteoporosis. Family and twin studies show that osteoporosis is a multi-gene regulation, strong hereditary diseases [1]. Morrison’s study have shown that vitamin D receptor has been associated with Bone Mineral Density (BMD), which is the major determinant of osteoporosis risk [3,4]. Vitamin D receptor gene is the most studied and controversial gene
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