Abstract
Vitamin D deficiency is associated with osteomalacia and a variety of musculoskeletal pain. This study aimed to determine the association of vitamin D deficiency with tibial bone pain and tenderness. Patients with leg pain, defined as local pain and tenderness over tibial bones for ≥6weeks were consecutively selected. Secondary causes of pain were excluded by appropriate clinical, radiological and laboratory examinations. Serum 25-hydroxyvitamin D (25-OHD) was assessed by enzyme-linked immunosorbent assay method and levels <20ng/mL were considered as deficiency. Age- and sex-matched subjects without leg pain served as controls. Multiple logistic regression analysis was used to determine associations. One hundred and eighteen patients and 114 controls aged 46.8±14.8 and 44.6±14.1years, respectively (P=0.93) were analyzed. Mean 25-OHD level was significantly lower (P=0.001) and the prevalence of 25-OHD deficiency was significantly higher in the patients as compared with the controls (75.4% vs. 23.6%), odds ratio (OR)=9.54 (95% CI, 5.22-17.45, P=0.001). There was a negative dose-response relationship between serum 25-OHD and tibial bone pain by OR=17.33 (95% CI, 6.48-46.3) in subjects with 25-OHD<10ng/mL, and OR=14.7 (95% CI, 6.35-34.6) in serum 25-OHD levels at 10-19.9ng/mL, and OR=2.58 (95% CI, 1.08-6.1) in those with 25-OHD at 20-29.9ng/mL as compared with 25-OHD≥30ng/mL. After controlling for demographic and biochemical factors, the association reached a stronger level of 19.8 (6.9-56.3) in subjects with serum 25-OHD<10ng/mL and 14.4 (5.8-34.6) in those with serum 25-OHD at levels of 10-19.9ng/mL and 1.85 (0.73-4.6) in 20-29ng/mL. These findings indicate a possible contributive role for serum 25-OHD deficiency in the development of pain and tenderness over the tibial bone.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call