Abstract
Aims: To investigate the association of vitamin D deficiency with cardiovascular autonomic nervous system function in children and adolescents with vasovagal syncope (VVS).Methods: This study recruited 76 pediatric patients with VVS and 15 healthy children. The 25-hydroxyvitamin D levels in serum among the participants were evaluated. Heart rate variability analysis including SDNN, rMSSD, and SDANN was tested in patients with VVS. The correlation between indices of time-domain analysis and serum vitamin D status of the children with VVS was investigated.Results: In this work, 25-hydroxyvitamin D levels in serum among VVS cases remarkably decreased compared with those among healthy controls (48.76 ± 19.25 vs. 67.62 ± 15.46 nmol/L, p < 0.01). The vitamin D deficient patients with VVS exhibited a lower rMSDD value compared to the non-deficient group with VVS (45.56 ± 16.87 vs. 61.90 ± 20.38 ms, p < 0.001, respectively). Pearson correlation analysis indicated that serum 25-hydroxyvitamin D levels had positive correlation with rMSDD values (r = 0.466, p < 0.001).Conclusions: As suggested by our data, VVS children and adolescents with vitamin D deficiency may have cardiac autonomic dysfunction and cardiac vagal tone decreases with the reduction in vitamin D level.
Highlights
Syncope is a common occurrence in the pediatric population
Compared with healthy control group, age, sex, body mass index (BMI), baseline blood pressure (BP), and baseline heart rate did not differ in children and adolescents with vasovagal syncope (VVS)
Our results suggest that hypovitaminosis D was common in children and adolescents with VVS at a rate of 60%
Summary
Syncope is a common occurrence in the pediatric population. Before the end of adolescence, about 15% of children and adolescents experience at least one episode of syncope [1, 2]. The most common etiology of syncope in pediatric patients is vasovagal syncope (VVS) [3]. It has been reported that orthostatic intolerance including VVS in children is associated with many malnutrition diseases, including low iron storage [5], vitamin B12 deficiency [6], vitamin B1 deficiency [7], and others. Vitamin D is one of fat-soluble nutritive molecules that is crucial for calcium and phosphorus homeostasis. Recent research has identified vitamin D as a prohormone with a wide range of actions in human diseases, in the cardiovascular system [8, 9]. It is related to the modulation of blood pressure, heart functions, coronary
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
