Abstract
Objective: The objective is a comparative analysis of vitamin D content and level of proinflammatory cytokines in infants born by mothers with endocrine disorders, and in infants of women with normal body weight.Methods: The clinic-anthropometrical and laboratory observation of 78 children born in Stavropol Regional Clinical Perinatal Centre: 36 infants were born by women with obesity and 18 – by women with gestational diabetes mellitus associated with obesity, 24 – by women who did not have obesity and clinical and laboratory signs of intolerance to glucose (control group). The level of calcidiol and interleukin 1β and 6 were determined in blood serum.Results: The content of vitamin D in infants born by healthy women was higher than in infants born by mothers with gestational diabetes mellitus associated with obesity and by mothers with obesity. Infants born by mothers with obesity had higher level of proinflammotary cytokines than those of control group.Conclusions: Children, born by mothers with endocrine disorders, have lower level of calcidiol and require postnatal prevention of vitamin D deficiency. Also it is necessary to take vitamin D during the pregnancy to prevent complications in pregnancy and neonatal pathology.
Highlights
The objective is a comparative analysis of vitamin D content and level of proinflammatory cytokines in infants born by mothers with endocrine disorders, and in infants of women with normal body weight
B rustman LE, Langer O, Bimson B, Scarpelli S, El Daouk M
Summary
Цель: сравнительный анализ обеспеченности витамином D и уровня провоспалительных цитокинов у младенцев, рожденных от матерей с эндокринной патологией, и у детей от женщин с нормальной массой тела. Обеспеченность витамином D детей, родившихся от здоровых женщин, была выше, чем детей от матерей с эндокринной патологией. Появившиеся на свет от матерей с ожирением, имели более высокий уровень провоспалительных цитокинов, чем в контроле. Рожденные от матерей с эндокринной патологией, имеют более низкий уровень кальцидиола и нуждаются в постнатальной профилактике гиповитаминоза D. Для цитирования: Захарова И.Н., Курьянинова В.А., Верисокина Н.Е., Атанесян Р.А., Климов Л.Я., Бобрышев Д.В., Железнякова Т.В., Кузьмина Е.М., Симонян А.В., Петросян М.А. Витамин D и провоспалительные цитокины у новорожденных от матерей с эндокринной патологией.
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