Vitamin B12 and Folic Acid Levels in Known Coronary Artery Disease Patients

Abstract

Vitamin B12 and folic acid are water soluble vitamins playing a vital role in various biological processes, where their deficiency leading to hyperhomocysteinemia are closely related to the development of cardio vascular risk. This case-control study included a total of 60 participants; 30 with confirmed coronary artery disease (CAD) and 30 were age and sex matched healthy controls. Fasting blood samples were collected and analyzed for biochemical parameters. Statistical analysis was done using SPSS software. A p value <0.05 was considered statistically significant. Vitamin B12 levels were found to be significantly lower in CAD patients than the controls. Based on the results, 50% of CAD patients had vitamin B12 deficiency. Vitamin B12 was positively associated with HDL-c and negatively with TC, TGL, LDL-c, VLDL-c, RLP-c, Non-HDL-c, TG/HDL-c. The study concludes that low levels of vitamin B12 and folic acid are related with risk factors of coronary artery disease