Abstract
larity producing an autologous extra-cellular matrix, replacing the degrading (65% MW reduction) PCL scaffold (11.3±4.0 vs. 31.4±9.2; Pb.0001). Morphometry and SEM showed 100% neoendothelialisation for both grafts. Intimal hyperplasia thickness, length and area were higher in ePTFE compared to PCL. Conclusions: Synthetic, biodegradable small-calibre nano-fibre polycaprolactone grafts show better patency, compliance, endothelialisation, less intimal hyperplasia and calcification compared to the clinically used ePTFE grafts after long-term implantation in the rat aorta. Thus, such novel in situ tissue engineered grafts could become a promising option for cardiovascular revascularisation procedures.
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