Visually guided reaching with the forelimb contralateral to a “blind” hemisphere in the monkey: contribution of the cerebellum

Abstract

Metabolic activity was mapped in the cerebellar cortex and its major inputs and projection targets in monkeys performing visually guided reaching with the left forelimb. Normal monkeys and monkeys deprived of visual input to the right cerebral hemisphere by right optic tract section, combined in some cases with forebrain commissurotomy, were studied. We reported previously that visually guided reaching with the left forelimb activated the motor cortex of the right hemisphere equally in all these monkeys, indicating that reaching was controlled by the right hemisphere whether it was visually intact or “blind” [Savaki H. E. et al. (1993) J. Neurosci. 13, 2772–2789]. In the present study, metabolic activations were observed in the left cerebellar hemispheric extensions of vermian lobules V, VI and VIII, again regardless of whether the right hemisphere was visually intact or “blind”. In intact monkeys, however, the activations were significantly smaller in the lateral than in the paravermal zone of these hemispheric extensions, whereas in tractotomized/commissurotomized monkeys the activations were equal in the two zones. The greater activations in the left lateral zone in tractotomized/commissurotomized monkeys may represent compensation in part for the visual deafferentation of the right cerebral hemisphere. Also observed were metabolic activation in the left dorsolateral pontine nucleus in tractotomized/commissurotomized monkeys and metabolic depression in the left dentate nucleus in visually intact monkeys. This pattern of results suggests the following conclusions. The activated loci in the left cerebellar cortex combine (i) visual information about the target relayed by seeing cerebral hemispheres, and (ii) sensorimotor information concerning intended and actual movements of the left forelimb relayed by the right cerebral hemisphere and the limb, respectively, and then (iii) send this integrated information back to the motor cortex of the right cerebral hemisphere, thus enabling it to guide the left forelimb to the target whether the hemisphere is visually intact or “blind”.