Abstract
The ability of cone photoreceptors to adapt to light is extraordinary. In this study we evaluated two biochemical processes, visual pigment phosphorylation and transducin translocation, for their ability to contribute to light adaptation in zebrafish cones. Since cytoplasmic Ca 2+ regulates light adaptation, the sensitivities of these processes to both light and Ca 2+ were examined. Cytoplasmic Ca 2+ regulates the sites of light-stimulated phosphorylation. Unexpectedly, we found that Ca 2+ also regulates the extent of phosphorylation of unbleached cone pigments. Immunocytochemical analyses revealed that neither light nor cytoplasmic Ca 2+ influences the localization of transducin in zebrafish cones.
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