Visible-Light-Promoted Cascade Carboxylation/Arylation of Unactivated Alkenes with CO2 for the Synthesis of Carboxylated Indole-Fused Heterocycles.

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Described here is a visible-light-promoted cascade carboxylation/arylation of indole-tethered unactivated alkenes with CO2 to access various carboxylated indole-fused heterocycles. This reaction is initiated by the addition of a CO2 radical anion to the alkene motif toward an alkyl carbon radical, followed by its addition to the aromatic ring, and then rearomatization to afford the final products. This reaction provides a facile and sustainable protocol for the construction of carboxylated indole-fused heterocycles using CO2 as the carboxylic source.