Abstract
AbstractA green and efficient method for the preparation of spirooxindole‐linked fused pyrans has been developed utilizing a catalyst‐free visible‐light‐driven one‐pot multicomponent reaction strategy. The reaction was performed in a water and ethanol mixture, using the combination of isatin, malononitrile, and cyclic 1,3‐dicarbonyls such as 4‐hydroxy‐1‐methyl‐2(1H)‐quinolone, 4‐hydroxycoumarin, 4‐hydroxythiocoumarin, or barbituric acid derivatives. This catalyst‐free, environmentally friendly, visible‐light‐driven, and room temperature method is a valuable addition to the synthetic toolbox for constructing complex heterocyclic scaffolds under one‐pot conditions. It holds promise for future applications in medicinal chemistry and drug discovery.
Published Version
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