Abstract
Main observation and conclusionA new method to access sulfonated dibenz[b,e]azepines via visible‐light photoredox catalysis is described. Employing inexpensive and commercially available sulfonyl chlorides to form the sulfonyl radicals enables the alkyne addition reaction followed by a 7‐membered radical cyclization step to furnish sulfonated dibenzazepines. In addition, an Ugi‐type multicomponent reaction (MCR) for the synthesis of o‐aminophenylacetylene derivatives can also be used as a rapid substrate synthesis method for the cascade radical cyclization protocol to obtain a series of highly functionalized sulfonylated dibenzazepines, which undoubtedly greatly simplifies the synthetic steps of the dibenzazepine compounds that are important core structures in pharmaceuticals.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call