Abstract
The present study was conducted to investigate the effect of concentration and temperature on viscosity of aspirin solution. In order to achieve better bioavailability of drug, it is necessary to make it soluble. Aqueous ethanol solutions have been taken as solvents. Aspirin solutions with different concentrations were prepared in aqueous ethanol. Viscosity values of the solutions were determined experimentally by using Ostwald viscometer at four different temperatures. The viscosity (η) data were used to calculate relative viscosity (ηr), Jone-Dole’s coefficient (BJ) and Falken Hagen coefficient (AF). Activation energy of viscous flow for the solvent (Δμ10∗), as well as for the solute (Δμ20∗) and other thermodynamic parameters like entropies (ΔS20∗) and enthalpies (ΔH20∗) of viscous flow were also calculated. All these physico-chemical parameters are important for understanding the molecular interactions present in the drug solutions. It has been found that strong solute–solvent interactions prevail over solute–solute interactions in the drug solutions. Negative values of (dBJ/dT) reveal that the drug aspirin acts as a structure promoter for the solutions under study.
Published Version
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