Abstract
Chemical cross-linking was used to create nanocomposite hydrogels made up of gelatin (G) and borosilicate bioactive glass (BBG) with different content (0, 3, and 5 wt.%). The G/BBG nanocomposite hydrogels were studied for their morphology, mechanical properties, and viscoelasticity. SEM images revealed a macroporous interconnected structure with particles scattered across the pore walls. Studies of water absorption and degradation confirmed that the nanocomposite scaffolds were hydrophilic and biodegradable. The addition of 5% BBG to the scaffold formulations increased the compressive modulus by 413% and the compressive intensity by 20%, respectively. At all frequency ranges tested, the storage modulus (G′) was greater than the loss modulus (G″), revealing a self-standing elastic nanocomposite hydrogel. The nanocomposite scaffolds facilitated apatite formation while immersed in simulated body fluid (SBF). According to the findings, G/BBG nanocomposite scaffolds could be a promising biomaterial for bone regeneration.
Highlights
Bone lesions are among the most difficult to treat and manage in medicine
On behalf of the Board of Directors, the USA Executive Committee has taken a range of steps to help members document COVID-19 problems surrounding organ donation and transplantation and to help members concentrate the necessary resources on critical clinical services in the short-term
A strain-controlled rheometer (Anton Paar Rheoplus V3.62—MCR 302, Graz, Austria) with a temperature sensor was used to test the rheological properties of the control gelatin hydrogel and the G/borosilicate bioactive glass (BBG) nanocomposite hydrogel samples
Summary
Bone lesions (such as fractures and tumors) are among the most difficult to treat and manage in medicine. On behalf of the Board of Directors, the USA Executive Committee has taken a range of steps to help members document COVID-19 problems surrounding organ donation and transplantation and to help members concentrate the necessary resources on critical clinical services (https: //optn.transplant.hrsa.gov, accessed on 29 April 2021) in the short-term Under these conditions, researchers are keen to find new ways to compensate for this organ shortage [3]. A scaffold is a natural or synthetic support used to design a biological substitute that, due to superior mechanical and structural properties, aims to provide a higher degree of satisfactory performance than the damaged tissue [6]. We are the first to prepare a gelatin(G)/BBG hydrogel nanocomposite for bone tissue engineering as a potential application
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