Visceral Adiposity Index and Lipid Accumulation Product Related to Insulin Resistance and Metabolic Syndrome in Obese College Students

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BACKGROUND: Visceral obesity in adolescent girls increased the risk of cardiometabolic disease. A simple indicator has been developed to assess metabolic risk through visceral adiposity index (VAI) and lipid accumulation product (LAP) in people with visceral obesity. AIM: This study analyzed the relationship between VAI and LAP with insulin resistance (IR) and metabolic syndrome (MS) in obese female adolescents. METHODS: An observational study was conducted on 120 students at Universitas Diponegoro. VAI was obtained from calculation formulations which includes body mass index, waist circumference (WC), triglycerides (TGs), and High-density lipoprotein (HDL) cholesterol. LAP was obtained from calculation formulation which include WC and TGs. IR values were obtained based on the calculation of homeostasis for assessment models IR. The metabolic syndrome score (cMetS) was obtained by the calculation of components of WC, blood pressure, fasting blood glucose, TG, and HDL cholesterol. Bivariate analysis using the Spearman Rank correlation test. RESULTS: We found that 40% of subjects had a VAI score that was considered at risk. As many as 20.8% of obese adolescent girls experience MetS while the other 79.2% are pre-metabolic syndrome and 83.3% of subjects have experienced IR. VAI showed a significant relationship with IR (p ≤ 0.001; r = 0.667) and cMetS (p = 0.007; p = 0.245). LAP showed a significant relationship with IR (p < 0,001; r = 0,385) and MS (p < 0,001; r = 0.372). CONCLUSION: We found that VAI and LAP could be an indicator for estimating IR and MS in obese female adolescent.